JBC: paper accepted!

Role of Δ1-Pyrroline-5-Carboxylate-dehydrogenase supports mitochondrial metabolism and host-cell invasion of Trypanosoma cruzi

Brian S. Mantilla, Lisvane S. PaesElizabeth M. F. PralDaiana E. MartilOtavio H. ThiemannPatricio Fernández-SilvaErick L. Bastosand Ariel M. Silber

Background: The enzyme, Δ1-pyrroline-5-carboxylate dehydrogenase (P5CDH), is a key enzyme involved in proline catabolism.

Results: The parasite, T. cruzi, upregulates P5CDH during host infection.

ConclusionT. cruzi uses P5C to produce energy, resist metabolic stress and invade host cells through this mitochondrial-bound enzyme.

Significance: The oxidation of P5C is sufficient to supply energy and enhance the pathogenicity of T. cruzi.