Role of Δ1-Pyrroline-5-Carboxylate-dehydrogenase supports mitochondrial metabolism and host-cell invasion of Trypanosoma cruzi
Brian S. Mantilla, Lisvane S. Paes, Elizabeth M. F. Pral, Daiana E. Martil, Otavio H. Thiemann, Patricio Fernández-Silva, Erick L. Bastos, and Ariel M. Silber
Background: The enzyme, Δ1-pyrroline-5-carboxylate dehydrogenase (P5CDH), is a key enzyme involved in proline catabolism.
Results: The parasite, T. cruzi, upregulates P5CDH during host infection.
Conclusion: T. cruzi uses P5C to produce energy, resist metabolic stress and invade host cells through this mitochondrial-bound enzyme.
Significance: The oxidation of P5C is sufficient to supply energy and enhance the pathogenicity of T. cruzi.
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